![Scheme 2. Computationally analyzed ring-opening reactions of epoxide 1... | Download Scientific Diagram Scheme 2. Computationally analyzed ring-opening reactions of epoxide 1... | Download Scientific Diagram](https://www.researchgate.net/publication/341718003/figure/fig2/AS:897516337913857@1590995978627/Scheme-2-Computationally-analyzed-ring-opening-reactions-of-epoxide-1-under-basic-1-a.png)
Scheme 2. Computationally analyzed ring-opening reactions of epoxide 1... | Download Scientific Diagram
![Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/D1OB01905H Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/D1OB01905H](https://pubs.rsc.org/image/article/2022/OB/d1ob01905h/d1ob01905h-f3_hi-res.gif)
Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/D1OB01905H
![a) Computationally analyzed epoxide ring-opening reactions under basic... | Download Scientific Diagram a) Computationally analyzed epoxide ring-opening reactions under basic... | Download Scientific Diagram](https://www.researchgate.net/publication/351895874/figure/fig3/AS:1029155026137089@1622381087845/a-Computationally-analyzed-epoxide-ring-opening-reactions-under-basic-left-and-acidic.jpg)
a) Computationally analyzed epoxide ring-opening reactions under basic... | Download Scientific Diagram
![SOLVED: In acidic conditions epoxides can be protonated. Protonated epoxides can undergo ring opening in the presence of poor nucleophiles: In these reactions the nucleophile preferentially attacks the more substituted carbon atom SOLVED: In acidic conditions epoxides can be protonated. Protonated epoxides can undergo ring opening in the presence of poor nucleophiles: In these reactions the nucleophile preferentially attacks the more substituted carbon atom](https://cdn.numerade.com/ask_images/ef3d5f01ebbe4320a1e99f11d61bd107.jpg)
SOLVED: In acidic conditions epoxides can be protonated. Protonated epoxides can undergo ring opening in the presence of poor nucleophiles: In these reactions the nucleophile preferentially attacks the more substituted carbon atom
![Regioselectivity of Epoxide Ring‐Openings via SN2 Reactions Under Basic and Acidic Conditions - Hansen - 2020 - European Journal of Organic Chemistry - Wiley Online Library Regioselectivity of Epoxide Ring‐Openings via SN2 Reactions Under Basic and Acidic Conditions - Hansen - 2020 - European Journal of Organic Chemistry - Wiley Online Library](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/f29894b4-e062-4f63-8fcc-2508db53680f/ejoc202000590-toc-0001-m.jpg)